Secreted clusterin inhibits tumorigenesis by modulating tumor cells and macrophages in human meningioma.

ABSTRACT:

Background

Meningioma is the most common primary intracranial tumor with a high frequency of postoperative recurrence, yet the biology of the meningioma malignancy process is still obscure.

Methods

To identify potential therapeutic targets and tumor suppressors, we performed single-cell transcriptome analysis through meningioma malignancy, which included 18 samples spanning normal meninges, benign and high-grade in situ tumors, and lung metastases, for extensive transcriptome characterization. Tumor suppressor candidate gene and molecular mechanism were functionally validated at the animal model and cellular levels.

Results

Comprehensive analysis and validation in mice and clinical cohorts indicated clusterin (CLU) had suppressive function for meningioma tumorigenesis

SUBMITTER: Ke C 

PROVIDER: S-EPMC11226886 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature