Sirtuin 2 regulates neutrophil functions through NAD⁺ synthesis pathway in virus infection.

ABSTRACT: Neutrophils play an important role in antiviral immunity, but the underlying mechanisms remain unclear. Here, we found that SIRT2 deficiency inhibited the infiltration of neutrophils, as well as the secretion of inflammatory cytokines and the formation of neutrophil extracellular traps (NETs), ameliorating disease symptoms during acute respiratory virus infection. Mechanistically, SIRT2 deficiency upregulates quinolinic acid (QA)-producing enzyme 3-hydroxyanthranilate oxygenase (3-HAO) and leads to expression of quinolinate phosphoribosyltransferase (QPRT), which promotes the synthesis of QA for NAD⁺ and limits viral infection when de novo NAD⁺ synthesis is blocked. Tryptophan-2,3-oxygenase expressed in epithelial cells metabolizes tryptophan to produce kynuren

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC11226967 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature