Ovomemolins: Egg-derived peptides that improved cognitive decline after oral administration in mice.

ABSTRACT: Eggs not only contain all the molecules necessary to nurture new life but are also rich in nutrients such as high-quality protein. For example, epidemiologic studies have shown that egg intake is positively correlated with cognitive function. Thus, we specifically examined the effect of ovalbumin, a major protein present in egg whites, on cognitive function. First, we found that an orally administered enzymatic digest of ovalbumin improves cognitive function in mice fed a high-fat diet. Then, we narrowed down candidate peptides based on the prediction of peptide production according to enzyme-substrate specificity and comprehensive peptide analysis of the digest. We found that three peptides, namely ILPEY, LYRGGLEP, and ILELP, improve cognitive function after oral administration. We also s

SUBMITTER: Nakajima T 

PROVIDER: S-EPMC11226991 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature