Probiotics and Antibiotic-Induced Microbial Aberrations in Children: A Secondary Analysis of a Randomized Clinical Trial.

ABSTRACT:

Importance

Probiotics are often considered in children to prevent antibiotic-associated diarrhea. However, the underlying mechanistic effects and impact of probiotics on antibiotic-induced microbiota changes are not well understood.

Objective

To investigate the effects of a multispecies probiotic on the gut microbiota composition in children receiving antibiotics.

Design, setting, and participants

This is a secondary analysis of a randomized, quadruple-blind, placebo-controlled clinical trial from February 1, 2018, to May 31, 2021, including 350 children receiving broad-spectrum antibiotics in the inpatient and outpatient settings. Patients were followed up until 1 month after the intervention period. Fecal samples and data were analyzed between September 1, 2022, and

SUBMITTER: Dierikx TH 

PROVIDER: S-EPMC11227081 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature