New insights into the hypothalamic-pituitary-thyroid axis: a transcriptome- and proteome-wide association study.

ABSTRACT:

Introduction

Thyroid hormones have systemic effects on the human body and play a key role in the development and function of virtually all tissues. They are regulated via the hypothalamic-pituitary-thyroid (HPT) axis and have a heritable component. Using genetic information, we applied tissue-specific transcriptome-wide association studies (TWAS) and plasma proteome-wide association studies (PWAS) to elucidate gene products related to thyrotropin (TSH) and free thyroxine (FT4) levels.

Results

TWAS identified 297 and 113 transcripts associated with TSH and FT4 levels, respectively (25 shared), including transcripts not identified by genome-wide association studies (GWAS) of these traits, demonstrating the increased power of this approach. Testing for genetic colocalization re

SUBMITTER: Monteiro-Martins S 

PROVIDER: S-EPMC11227097 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature