Interaction mechanism of oseltamivir phosphate with bovine serum albumin: multispectroscopic and molecular docking study.

ABSTRACT: Oseltamivir phosphate (OP) is an antiviral drug with potential risks to human health due to overuse, leading to serious consequences such as gastrointestinal disturbances, abnormal neuropsychiatric symptoms, and sudden death. Therefore, gaining an in-depth understanding of its interaction with proteins is crucial. We investigated the interaction between OP and bovine serum albumin (BSA) utilizing multispectral methods (i.e., fluorescence, ultraviolet absorption, circular dichroism) combined with molecular docking techniques. Fluorescence spectroscopy indicated that OP quenched BSA fluorescence by forming the OP-BSA complex. The Stern-Volmer constants (K_SV) between OP and BSA were determined to be 3.06 × 10³ L/mol, 2.36 × 10³ L/mol, and 1.86 × 10³

SUBMITTER: Yu J 

PROVIDER: S-EPMC11227190 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature