CALU promotes lung adenocarcinoma progression by enhancing cell proliferation, migration and invasion.

ABSTRACT:

Background

Lung cancer is the second most common cancer with the highest mortality in the world. Calumenin as a molecular chaperone that not only binds various proteins within the endoplasmic reticulum but also plays crucial roles in diverse processes associated with tumor development. However, the regulatory mechanism of calumenin in lung adenocarcinoma remains elusive. Here, we studied the impact of calumenin on lung adenocarcinoma and explored possible mechanisms.

Methods

5-ethynyl-2'-deoxyuridine assay, colony formation, transwell and wound healing assays were performed to explore the effects of calumenin on the proliferation and migration of lung adenocarcinoma cells. To gain insights into the underlying mechanisms through which calumenin knockdown inhibits the migratio

SUBMITTER: Li Y 

PROVIDER: S-EPMC11227236 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature