Fecal microbiota transplantation alters gut phage communities in a clinical trial for obesity.

ABSTRACT:

Background

Fecal microbiota transplantation (FMT) is a therapeutic intervention used to treat diseases associated with the gut microbiome. In the human gut microbiome, phages have been implicated in influencing human health, with successful engraftment of donor phages correlated with FMT treatment efficacy. The impact that gastrointestinal phages exert on human health has primarily been connected to their ability to modulate the bacterial communities in the gut. Nonetheless, how FMT affects recipients' phage populations, and in turn, how this influences the gut environment, is not yet fully understood. In this study, we investigated the effects of FMT on the phageome composition of participants within the Gut Bugs Trial (GBT), a double-blind, randomized, placebo-controlled trial th

SUBMITTER: Zuppi M 

PROVIDER: S-EPMC11227244 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature