Reduced dynamic changes in pulmonary artery compliance during isometric handgrip exercise in patients with heart failure.

ABSTRACT: Exercise intolerance is a debilitating symptom in heart failure (HF), adversely affecting both quality of life and long-term prognosis. Emerging evidence suggests that pulmonary artery (PA) compliance may be a contributing factor. This study aims to non-invasively assess PA compliance and its dynamic properties during isometric handgrip (HG) exercise in HF patients and healthy controls, using cardiovascular magnetic resonance (CMR). We prospectively enrolled 36 subjects, comprising 17 HF patients (NYHA class II and III) and 19 healthy controls. Participants performed an HG test, and we assessed changes in PA compliance and hemodynamic flow parameters using advanced CMR techniques. We also explored the relationship between CMR-derived PA compliance metrics and established clinical indicator

SUBMITTER: Hashemi D 

PROVIDER: S-EPMC11227514 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature