Tetrafluoroisopropylation of alkenes and alkynes enabled by photocatalytic consecutive difluoromethylation with CF₂HSO₂Na.

ABSTRACT: Direct assembly of complex fluorinated motifs from simple fluorine sources is an attractive frontier of synthetic chemistry. Reported herein is an unconventional protocol for achieving tetrafluoroisopropylation by using commercially available CF₂HSO₂Na as a convenient source of the tetrafluoroisopropyl [(CF₂H)₂CH] group, which finds widespread applications in life science and material science. Visible-light-induced hydrotetrafluoroisopropylation of alkenes and carbotetrafluoroisopropylation of alkynes have been thus developed. Various structurally diverse α-tetrafluoroisopropyl carbonyls and cyclopentanones are selectively constructed under mild conditions. A photocatalytic triple difluoromethylation cascade, driven by consecutive reductive radic

SUBMITTER: Hong Y 

PROVIDER: S-EPMC11227567 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature