Essential role of p21^Waf1/Cip1 in the modulation of post-traumatic hippocampal Neural Stem Cells response.

ABSTRACT:

Background

Traumatic Brain Injury (TBI) represents one of the main causes of brain damage in young people and the elderly population with a very high rate of psycho-physical disability and death. TBI is characterized by extensive cell death, tissue damage and neuro-inflammation with a symptomatology that varies depending on the severity of the trauma from memory loss to a state of irreversible coma and death. Recently, preclinical studies on mouse models have demonstrated that the post-traumatic adult Neural Stem/Progenitor cells response could represent an excellent model to shed light on the neuro-reparative role of adult neurogenesis following damage. The cyclin-dependent kinase inhibitor p21^Waf1/Cip1 plays a pivotal role in modulating the quiescence/activation balanc

SUBMITTER: Chiani F 

PROVIDER: S-EPMC11227726 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature