Maintenance proton pump inhibitor use and risk of colorectal cancer: a Swedish retrospective cohort study.

ABSTRACT:

Objectives

We aimed to evaluate the risk of colorectal adenocarcinoma (CRA) associated with long-term use of proton pump inhibitors (PPIs) in a large nationwide cohort.

Design

Retrospective cohort study.

Setting

This research was conducted at the national level, encompassing the entire population of Sweden.

Participants

This study utilised Swedish national registries to identify all adults who had ≥180 days of cumulative PPI use between July 2005 and December 2012, excluding participants who were followed up for less than 1 year. A total of 754 118 maintenance PPI users were included, with a maximum follow-up of 7.5 years.

Interventions

Maintenance PPI use (cumulative≥180 days), with a comparator of maintenance histamine-2 receptor antagonist (H₂

SUBMITTER: Liu Q 

PROVIDER: S-EPMC11227764 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature