Intravenous ketamine for emergency department treatment of suicidal ideation in a paediatric population: protocol for a double-blind, randomised, placebo-controlled, parallel-arm pilot trial (KSI study).

ABSTRACT:

Introduction

Suicidal ideation (SI) is a common and severe cause of morbidity in adolescents. Patients frequently present to the emergency department (ED) for care, yet there is no acute therapeutic intervention for SI. A single dose of intravenous ketamine has demonstrated efficacy in rapidly reducing SI in adults; however, ketamine has not been studied in paediatrics. We aim to determine the feasibility of a trial of a single intravenous ketamine dose to reduce SI for patients in the paediatric ED.

Methods and analysis

This will be a single-centre, double-blind, randomised, placebo-controlled, parallel-arm pilot trial of intravenous ketamine for ED treatment of SI in a paediatric population.

Intervention

one intravenous dose of 0.5 mg/kg of ketamine (max 50 mg), ove

SUBMITTER: Schlegelmilch M 

PROVIDER: S-EPMC11227786 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature