Imaging predictors of 4q12 amplified and RB1 mutated glioblastoma IDH-wildtype.

ABSTRACT:

Introduction

Recent studies have identified that glioblastoma IDH-wildtype consists of different molecular subgroups with distinct prognoses. In order to accurately describe and classify gliomas, the Visually AcceSAble Rembrandt Images (VASARI) system was developed. The goal of this study was to evaluate the VASARI characteristics in molecular subgroups of IDH-wildtype glioblastoma.

Methods

A retrospective analysis of glioblastoma IDH- wildtype with comprehensive next-generation sequencing and pre-operative and post-operative MRI was performed. VASARI characteristics and 205 genes were evaluated. Multiple comparison adjustment by the Bejamin-Hochberg false discovery rate (BH-FDR) was performed. A 1:3 propensity score match (PSM) with a Caliper of 0.2 was done.

Results

SUBMITTER: Dono A 

PROVIDER: S-EPMC11227885 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature