Umbilical cord blood-derived therapy for preterm lung injury: a systematic review and meta-analysis.

ABSTRACT:

Introduction

Lung injuries, such as bronchopulmonary dysplasia (BPD), remain a major complication of preterm birth, with limited therapeutic options. One potential emerging therapy is umbilical cord blood (UCB)-derived therapy.

Objectives

To systematically assess the safety and efficacy of UCB-derived therapy for preterm lung injury in preclinical and clinical studies.

Methods

A systematic search of MEDLINE, Embase, CENTRAL, ClinicalTrials.gov, and WHO International Trials Registry Platform was performed. A meta-analysis was conducted with Review Manager (5.4.1) using a random effects model. Data was expressed as standardized mean difference (SMD) for preclinical data and pooled relative risk (RR) for clinical data, with 95% confidence intervals (CI). Potential effect

SUBMITTER: Purcell E 

PROVIDER: S-EPMC11227974 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature