Identification and validation of a prognostic model based on four genes related to satellite nodules in hepatocellular carcinoma.

ABSTRACT: Satellite nodules is a key clinical characteristic which has prognostic value of hepatocellular carcinoma (HCC). Currently, there is no gene-level predictive model for Satellite nodules in liver cancer. For the 377 HCC cases collected from the dataset of Cancer Genome Atlas (TCGA), their original pathological data were analyzed to extract information regarding satellite nodules status as well as other relevant pathological data. Then, this study employed statistical modeling for prognostic model establishment in TCGA, and validation in International Cancer Genome Consortium (ICGC) cohorts and GSE76427. Through rigorous statistical analyses, 253 differential satellite nodules-related genes (SNRGs) were identified, and four key genes related to satellite nodules and prognosis were selected t

SUBMITTER: Liu F 

PROVIDER: S-EPMC11228042 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature