Impaired arginine/ornithine metabolism drives severe HFMD by promoting cytokine storm.

ABSTRACT:

Introduction

The Hand, Foot and Mouth Disease (HFMD), caused by enterovirus 71 infection, is a global public health emergency. Severe HFMD poses a significant threat to the life and well-being of children. Numerous studies have indicated that the occurrence of severe HFMD is associated with cytokine storm. However, the precise molecular mechanism underlying cytokine storm development remains elusive, and there are currently no safe and effective treatments available for severe HFMD in children.

Methods

In this study, we established a mouse model of severe HFMD to investigate the molecular mechanisms driving cytokine storm. We specifically analyzed metabolic disturbances, focusing on arginine/ornithine metabolism, and assessed the potential therapeutic effects of spermine, an

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11228176 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature