Genomic epidemiology of Mycobacterium abscessus at an adult cystic fibrosis programme reveals low potential for healthcare-associated transmission.

ABSTRACT:

Rationale

Nontuberculous mycobacteria (NTM) has been reported to be transmitted between people with cystic fibrosis (CF) attending CF centres. A suspected Mycobacterium abscessus outbreak was investigated at the University of Texas Southwestern (UTSW) Adult CF Program using a combination of pathogen genomic sequencing and epidemiologic methods. The objectives of the present study were to apply the Healthcare-Associated Links in Transmission of NTM (HALT NTM) study to investigate the occurrence of potential healthcare-associated transmission and/or acquisition of NTM among people with CF infected with genetically similar NTM isolates.

Methods

Whole-genome sequencing of respiratory M. abscessus isolates from 50 people with CF receiving care at UTSW was performed

SUBMITTER: Gross JE 

PROVIDER: S-EPMC11228611 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature