Natural products for Gut-X axis: pharmacology, toxicology and microbiology in mycotoxin-caused diseases.

ABSTRACT: Introduction: The gastrointestinal tract is integral to defending against external contaminants, featuring a complex array of immunological, physical, chemical, and microbial barriers. Mycotoxins, which are toxic metabolites from fungi, are pervasive in both animal feed and human food, presenting substantial health risks. Methods: This review examines the pharmacological, toxicological, and microbiological impacts of natural products on mycotoxicosis, with a particular focus on the gut-x axis. The analysis synthesizes current understanding and explores the role of natural products rich in polysaccharides, polyphenols, flavonoids, and saponins. Results: The review highlights that mycotoxins can disrupt intestinal integrity, alter inflammatory responses, damage the mucus

SUBMITTER: Li K 

PROVIDER: S-EPMC11228701 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature