Molecular adaptations in response to exercise training are associated with tissue-specific transcriptomic and epigenomic signatures.

ABSTRACT: Regular exercise has many physical and brain health benefits, yet the molecular mechanisms mediating exercise effects across tissues remain poorly understood. Here we analyzed 400 high-quality DNA methylation, ATAC-seq, and RNA-seq datasets from eight tissues from control and endurance exercise-trained (EET) rats. Integration of baseline datasets mapped the gene location dependence of epigenetic control features and identified differing regulatory landscapes in each tissue. The transcriptional responses to 8 weeks of EET showed little overlap across tissues and predominantly comprised tissue-type enriched genes. We identified sex differences in the transcriptomic and epigenomic changes induced by EET. However, the sex-biased gene responses were linked to shared signaling pathways. We found

SUBMITTER: Nair VD 

PROVIDER: S-EPMC11228891 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature