A diagnostic model for Parkinson's disease based on circadian rhythm-related genes.

ABSTRACT:

Background

Circadian rhythm (CR) disturbance is intricately associated with Parkinson's disease (PD). However, the involvement of CR-related mechanisms in the pathogenesis and progression of PD remains elusive.

Methods

A total of 141 PD patients and 113 healthy participants completed CR-related clinical examinations in this study. To further investigate the CR-related mechanisms in PD, we obtained datasets (GSE7621, GSE20141, GSE20292) from the Gene Expression Omnibus database to identify differentially expressed genes between PD patients and healthy controls and further selected CR-related genes (CRRGs). Subsequently, the least absolute shrinkage and selection operator (LASSO) followed by logistic algorithms were employed to identify the hub genes and construct a diagnostic

SUBMITTER: Wang L 

PROVIDER: S-EPMC11229228 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature