Application prospects of the 2BS cell-adapted China fixed rabies virus vaccine strain 2aG4-B40.

ABSTRACT:

Background

Rabies is a fatal zoonotic disease whose pathogenesis has not been fully elucidated, and vaccination is the only effective method for protecting against rabies virus infection. Most inactivated vaccines are produced using Vero cells, which are African green monkey kidney cells, to achieve large-scale production. However, there is a potential carcinogenic risk due to nonhuman DNA contamination. Thus, replacing Vero cells with human diploid cells may be a safer strategy. In this study, we developed a novel 2BS cell-adapted rabies virus strain and analysed its sequence, virulence and immunogenicity to determine its application potential as a human diploid cell inactivated vaccine.

Methods and results

The 2BS cell-adapted rabies virus strain 2aG4-B40 was established b

SUBMITTER: Xu Y 

PROVIDER: S-EPMC11229241 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature