Vaginal and rectal microbiome contribute to genital inflammation in chronic pelvic pain.

ABSTRACT:

Background

Chronic pelvic pain (CPP) is a multifactorial syndrome that can substantially affect a patient's quality of life. Endometriosis is one cause of CPP, and alterations of the immune and microbiome profiles have been observed in patients with endometriosis. The objective of this pilot study was to investigate differences in the vaginal and gastrointestinal microbiomes and cervicovaginal immune microenvironment in patients with CPP and endometriosis diagnosis compared to those with CPP without endometriosis and no CPP.

Methods

Vaginal swabs, rectal swabs, and cervicovaginal lavages (CVL) were collected among individuals undergoing gynecologic laparoscopy. Participants were grouped based on patients seeking care for chronic pain and/or pathology results: CPP and endomet

SUBMITTER: Jimenez N 

PROVIDER: S-EPMC11229265 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature