Association of Immune Cell Subsets with Incident Hip Fracture: The Cardiovascular Health Study.

ABSTRACT: In this study, we aimed to evaluate the association of innate and adaptive immune cell subsets in peripheral blood mononuclear cells (PBMCs) with hip fracture. To conduct this study, we used data from the Cardiovascular Health Study (CHS), a U.S. multicenter observational cohort of community-dwelling men and women aged ≥ 65 years. Twenty-five immune cell phenotypes were measured by flow cytometry from cryopreserved PBMCs of CHS participants collected in 1998-1999. The natural killer (NK), γδ T, T helper 17 (Th17), and differentiated/senescent CD4⁺CD28^- T cell subsets were pre-specified as primary subsets of interest. Hip fracture incidence was assessed prospectively by review of hospitalization records. Multivariable Cox hazard models evaluated associations of immune

SUBMITTER: Elam RE 

PROVIDER: S-EPMC11229516 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature