Mycolyltransferase is important for biofilm formation and pathogenesis of Tsukamurella keratitis.

ABSTRACT: Tsukamurella, a group of multi-drug resistant, Gram-positive, aerobic, and partially acid-fast bacteria, are emerging causes of bacterial conjunctivitis and keratitis. However, the pathogenesis of Tsukamurella keratitis is largely unknown. To address this, we used New Zealand White rabbits to develop the first eye infection model and conducted in vitro tests to study the pathogenesis mechanisms of Tsukamurella. There is increasing evidence that biofilms play a significant role in ocular infections, leading us to hypothesize that biofilm formation is crucial for effective Tsukamurella infection. In order to look for potential candidate genes which are important in biofilm formation and Tsukamurella keratitis. We performed genome sequencing of two oc

SUBMITTER: Teng JL 

PROVIDER: S-EPMC11229725 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature