Adipogenic differentiation of hematopoietic lineage cells isolated from adipose tissue of humans.

ABSTRACT: We previously discovered some adipocytes in the major white fat depots of mice and humans arise from bone marrow-derived cells of hematopoietic lineage rather than conventional mesenchymal precursors, termed bone marrow-derived adipocytes (BMDA). Here we aimed to determine if hematopoietic lineage cells isolated from adipose tissue and circulation of humans could undergo adipogenic differentiation in vitro, thereby establishing an in vitro model for studies of BMDA. We hypothesized that hematopoietic lineage cells isolated from adipose tissue, but not circulation, of humans would demonstrate adipogenic potential. Participants included younger (20-50 years) and older (>50-75 years) men and women, BMI 20-37 kg/m². Subcutaneous abdominal adipose tissue biopsies were o

SUBMITTER: Gavin KM 

PROVIDER: S-EPMC11230218 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature