Stereotyped spatiotemporal dynamics of spontaneous activity in visual cortex prior to eye-opening.

ABSTRACT: Over the course of development, functional sensory representations emerge in the visual cortex. Prior to eye-opening, modular patterns of spontaneous activity form long-range networks that may serve as a precursor for mature network organization. Although the spatial structure of these networks has been well studied, their temporal features, which may contribute to their continued plasticity and development, remain largely uncharacterized. To address this, we imaged hours of spontaneous network activity in the visual cortex of developing ferrets of both sexes utilizing a fast calcium indicator (GCaMP8m) and widefield imaging at high temporal resolution (50Hz), then segmented out spatiotemporal events. The spatial structure of this activity was highly modular, exhibiting spatially segregate

SUBMITTER: Kettlewell L 

PROVIDER: S-EPMC11230236 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature