Dynamic changes in subplate and cortical plate microstructure at the onset of cortical folding in vivo.

ABSTRACT: Cortical gyrification takes place predominantly during the second to third trimester, alongside other fundamental developmental processes, such as the development of white matter connections, lamination of the cortex and formation of neural circuits. The mechanistic biology that drives the formation cortical folding patterns remains an open question in neuroscience. In our previous work, we modelled the in utero diffusion signal to quantify the maturation of microstructure in transient fetal compartments, identifying patterns of change in diffusion metrics that reflect critical neurobiological transitions occurring in the second to third trimester. In this work, we apply the same modelling approach to explore whether microstructural maturation of these compartments is correlated with the p

SUBMITTER: Wilson S 

PROVIDER: S-EPMC11230247 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature