Dosimetry of [⁶⁴Cu]FBP8: a fibrin-binding PET probe.

ABSTRACT:

Purpose

This study presents the biodistribution, clearance and dosimetry estimates of [⁶⁴Cu]Fibrin Binding Probe #8 ([⁶⁴Cu]FBP8) in healthy subjects.

Procedures

This prospective study included 8 healthy subjects to evaluate biodistribution, safety and dosimetry estimates of [⁶⁴Cu]FBP8, a fibrin-binding positron emission tomography (PET) probe. All subjects underwent up to 3 sessions of PET/Magnetic Resonance Imaging (PET/MRI) 0-2 hours, 4h and 24h post injection. Dosimetry estimates were obtained using OLINDA 2.2 software.

Results

Subjects were injected with ~400 MBq of [⁶⁴Cu]FBP8. Subjects did not experience adverse effects due to the injection of the probe. [⁶⁴Cu]FBP8 PET images demonstrated fast blood clearance

SUBMITTER: Izquierdo-Garcia D 

PROVIDER: S-EPMC11230308 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature