Impact of dosing schedules on performance of rotavirus vaccines in Ghana.

ABSTRACT:

Background

Available live-oral rotavirus vaccines are associated with low to moderate performance in low- and middle-income settings. There is limited evidence relating to how the vaccine dosing schedule might be adjusted to improve vaccine performance in these settings.

Methods

We used mathematical models fitted to rotavirus surveillance data for children <5 years of age from three different hospitals in Ghana (Korle-Bu Teaching Hospital in Accra, Komfo Anokye Teaching Hospital in Kumasi and War Memorial Hospital in Navrongo) to project the impact of rotavirus vaccination over a 10-year period (April 2012-March 2022). We quantified and compared the impact of the previous vaccination program in Ghana to the model-predicted impact for other vaccine dosing schedules across the

SUBMITTER: Asare EO 

PROVIDER: S-EPMC11230340 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature