Gut-to-brain regulation of <i>Drosophila</i> aging through neuropeptide F, insulin and juvenile hormone.

ABSTRACT: Dietary restriction slows aging in many animals, while in some cases the sensory signals from diet alone are sufficient to retard or accelerate lifespan. The digestive tract is a candidate location to sense nutrients, where neuropeptides secreted by enteroendocrine cells (EEC) produce systemic signals in response to food. Here we measure how Drosophila neuropeptide F (NPF) is secreted into adult circulation by enteroendocrine cells and find that specific enteroendocrine cells differentially respond to dietary sugar and yeast. Lifespan is increased when gut NPF is genetically depleted, and this manipulation is sufficient to blunt the longevity benefit conferred by dietary restriction. Depletion of NPF receptors at insulin producing neurons of the brain also increases lifespan, consis

SUBMITTER: Chen J 

PROVIDER: S-EPMC11230353 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature