Cell type-specific inhibitory modulation of sound processing in the auditory thalamus.

ABSTRACT: Inhibition plays an important role in controlling the flow and processing of auditory information throughout the central auditory pathway, yet how inhibition shapes auditory processing in the medial geniculate body (MGB), the key region in the auditory thalamus, is poorly understood. MGB gates the flow of auditory information to the auditory cortex, and it is inhibited largely by the thalamic reticular nucleus (TRN). The TRN comprises two major classes of inhibitory neurons: parvalbumin (PV^TRN)-positive and somatostatin (SST^TRN)-positive neurons. PV and SST neurons have been shown to play differential roles in controlling sound responses in other brain regions. In the somatosensory and visual subregions of the TRN, PV^TRN and SST^TRN neurons exhibi

SUBMITTER: Rolon-Martinez S 

PROVIDER: S-EPMC11230419 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature