A simulation study on the antiarrhythmic mechanisms of established agents in myocardial ischemia and infarction.

ABSTRACT: Patients with myocardial ischemia and infarction are at increased risk of arrhythmias, which in turn, can exacerbate the overall risk of mortality. Despite the observed reduction in recurrent arrhythmias through antiarrhythmic drug therapy, the precise mechanisms underlying their effectiveness in treating ischemic heart disease remain unclear. Moreover, there is a lack of specialized drugs designed explicitly for the treatment of myocardial ischemic arrhythmia. This study employs an electrophysiological simulation approach to investigate the potential antiarrhythmic effects and underlying mechanisms of various pharmacological agents in the context of ischemia and myocardial infarction (MI). Based on physiological experimental data, computational models are developed to simulate the effects

SUBMITTER: Li Q 

PROVIDER: S-EPMC11230589 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature