Differences in the consolidation by spontaneous and evoked ripples in the presence of active dendrites.

ABSTRACT: Ripples are a typical form of neural activity in hippocampal neural networks associated with the replay of episodic memories during sleep as well as sleep-related plasticity and memory consolidation. The emergence of ripples has been observed both dependent as well as independent of input from other brain areas and often coincides with dendritic spikes. Yet, it is unclear how input-evoked and spontaneous ripples as well as dendritic excitability affect plasticity and consolidation. Here, we use mathematical modeling to compare these cases. We find that consolidation as well as the emergence of spontaneous ripples depends on a reliable propagation of activity in feed-forward structures which constitute memory representations. This propagation is facilitated by excitable dendrites, which ent

SUBMITTER: Jauch J 

PROVIDER: S-EPMC11230591 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature