How can road safety be improved? The BMJ asked four experts for their views : More people die on the roads than from malaria, says WHO chief
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PROVIDER: S-EPMC1123087 | biostudies-literature | 2002 May
REPOSITORIES: biostudies-literature
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Project description: Not available
| S-EPMC1479623 | biostudies-literature
Project description:IntroductionA disabling and disfiguring disease that "begins where the road ends", yaws is targeted by WHO for eradication by the year 2020. The global campaign is not yet financed. To evaluate yaws eradication within the context of the post-2015 development agenda, we perform a somewhat allegorical cost-effectiveness analysis of eradication, comparing it to a counterfactual in which we simply wait for more roads (the end of poverty).MethodsWe use evidence from four yaws eradication pilot sites and other mass treatment campaigns to set benchmarks for the cost of eradication in 12 known endemic countries. We construct a compartmental model of long-term health effects to 2050. Conservatively, we attribute zero cost to the counterfactual and allow for gradual exit of the susceptible (at risk) population by road (poverty reduction). We report mean, 5th and 95th centile estimates to reflect uncertainty about costs and effects.ResultsOur benchmark for the economic cost of yaws eradication is uncertain but not high -US$ 362 (75-1073) million in 12 countries. Eradication would cost US$ 26 (4.2-78) for each year of life lived without disability or disfigurement due to yaws, or US$ 324 (47-936) per disability-adjusted life year (DALY). Excluding drugs, existing staff and assets, the financial cost benchmark is US$ 213 (74-522) million. The real cost of waiting for more roads (poverty reduction) would be 13 (7.3-20) million years of life affected by early-stage yaws and 2.3 (1.1-4.2) million years of life affected by late-stage yaws.DiscussionEndemic countries need financing to begin implementing and adapting global strategy to local conditions. Donations of drugs and diagnostics could reduce cost to the public sector and catalyze financing. Resources may be harnessed from the extractive industries. Yaws eradication should be seen as complementary to universal health coverage and shared prosperity on the post-2015 development agenda.
| S-EPMC4177754 | biostudies-literature
Project description: Not available
| S-EPMC1123088 | biostudies-literature
Project description:The presence of intensive livestock farms in close vicinity to residential areas in the Netherlands is a complex problem characterised by knowledge uncertainty about the effects on residential health, overlapping value-driven concerns and stakeholder diversity. In order to address concerns about the health effects and effectively manage the debate about intensive livestock farming, constructive stakeholder dialogues are encouraged, informed by current scientific insights. We explored the current knowledge, beliefs and concerns of scientific experts, following the mental models approach. A summary expert model was derived from scanning the relevant literature and informed by interviews with 20 scientific experts. The study shows imprecise use of terminology by experts. Moreover, they appear to perceive intensive livestock farming not as a major health problem at least at this moment for neighbouring residents in the Netherlands. Broader themes such as (environmental) unsustainability and biodiversity loss seem a more prominent concern among the experts. Our study questions whether dialogues should only focus on residential health or cover broader values and concerns. However, mental models about risk may differ with other stakeholders, impeding communication. Hence, we will identify other stakeholders' knowledge, beliefs and value-based concerns in the light of facilitating constructed dialogues between stakeholders.
| S-EPMC6801788 | biostudies-literature
Project description:Accurate pose estimation is a fundamental ability that all mobile robots must posses in order to navigate a given environment. Much like a human, this ability is dependent on the robot's understanding of a given scene. For autonomous vehicles (AVs), detailed 3D maps created beforehand are widely used to augment the perceptive abilities and estimate pose based on current sensor measurements. This approach, however, is less suited for rural communities that are sparsely connected and cover large areas. Topological maps such as OpenStreetMap have proven to be a useful alternative in these situations. However, vehicle localization using these maps is non-trivial, particularly for the global localization task, where the map spans large areas. To deal with this challenge, we propose road descriptors along with an initialization technique for localization that allows for fast global pose estimation. We test our algorithms on (real world) maps and benchmark them against other map-based localization as well as SLAM algorithms. Our results show that the proposed method can narrow down the pose to within 50 cm of the ground truth significantly faster than the state-of-the-art methods.
| S-EPMC10537067 | biostudies-literature
Project description: Not available
| S-EPMC2831687 | biostudies-literature
Project description:We investigate the link between birth order and the career outcome of becoming Chief Executive Officer (CEO) of a company. CEOs are more likely to be the first-born, i.e., oldest, child of their family relative to what one would expect if birth order did not matter for career outcomes. Both male and female CEOs are more likely to be first-born. However, the first-born advantage seems to largely reflect the absence of an older brother, but not of an older sister. These results are more pronounced for family firms, where traditionally the oldest child is appointed to run the family business, but also hold for non-family firms.
| S-EPMC7326194 | biostudies-literature
Project description: Not available
| S-EPMC11332137 | biostudies-literature
Project description:The Chinese government promotes the Belt and Road Initiative (BRI) as a global strategy for regional integration and infrastructure investment. With a projected US$1 trillion commitment from Chinese financial institutions, and at least 138 countries participating, the BRI is attracting intense debate. Yet most analysis to date focuses on broad drivers, risks, and opportunities, largely considered to be emanating from a coherent policy imposed by Beijing. In this special issue, we instead examine the BRI as a relational, contested process - a bundle of intertwined discourses, policies, and projects that sometimes align but are sometimes contradictory. We move beyond policy-level, macro-economic, and classic geopolitical analysis to study China's global investments "from the ground". Our case studies reveal the BRI to be dynamic and unstable, rhetorically appropriated for different purposes that sometimes but do not always coalesce as a coherent geopolitical and geoeconomic strategy. The papers in this special issue provide one of the first collections of deep empirical work on the BRI and a useful approach for grounding China's role in globalization in the critical contexts of complex local realities.
| S-EPMC7398643 | biostudies-literature
Project description:BackgroundGene drive technologies (GDTs) promote the rapid spread of a particular genetic element within a population of non-human organisms. Potential applications of GDTs include the control of insect vectors, invasive species and agricultural pests. Whether, and if so, under what conditions, GDTs should be deployed is hotly debated. Although broad stances in this debate have been described, the convictions that inform the moral views of the experts shaping these technologies and related policies have not been examined in depth in the academic literature.MethodsIn this qualitative study, we interviewed GDT experts (n = 33) from different disciplines to identify and better understand their moral views regarding these technologies. The pseudonymized transcripts were analyzed thematically.ResultsThe respondents' moral views were principally influenced by their attitudes towards (1) the uncertainty related to GDTs; (2) the alternatives to which they should be compared; and (3) the role humans should have in nature. Respondents agreed there is epistemic uncertainty related to GDTs, identified similar knowledge gaps, and stressed the importance of realistic expectations in discussions on GDTs. They disagreed about whether uncertainty provides a rationale to refrain from field trials ('risks of intervention' stance) or to proceed with phased testing to obtain more knowledge given the harms of the status quo ('risks of non-intervention' stance). With regards to alternatives to tackle vector-borne diseases, invasive species and agricultural pests, respondents disagreed about which alternatives should be considered (un)feasible and (in)sufficiently explored: conventional strategies ('downstream solutions' stance) or systematic changes to health care, political and agricultural systems ('upstream solutions' stance). Finally, respondents held different views on nature and whether the use of GDTs is compatible with humans' role in nature ('interference' stance) or not ('non-interference stance').ConclusionsThis interview study helps to disentangle the debate on GDTs by providing a better understanding of the moral views of GDT experts. The obtained insights provide valuable stepping-stones for a constructive debate about underlying value conflicts and call attention to topics that deserve further (normative) reflection. Further evaluation of these issues can facilitate the debate on and responsible development of GDTs.
| S-EPMC7938529 | biostudies-literature