FERMT1 suppression induces anti-tumor effects and reduces stemness in glioma cancer cells.

ABSTRACT:

Objective

Glioma is a leading cause of mortality worldwide, its recurrence poses a major challenge in achieving effective treatment outcomes. Cancer stem cells (CSCs) have emerged as key contributors to tumor relapse and chemotherapy resistance, making them attractive targets for glioma cancer therapy. This study investigated the potential of FERMT1 as a prognostic biomarker and its role in regulating stemness through cell cycle in glioma.

Methods

Using data from TCGA-GBM, GSE4290, GSE50161 and GSE147352 for analysis of FERMT1 expression in glioma tissues. Then, the effects of FERMT1 knockdown on cell cycle, proliferation, sphere formation ability, invasion and migration were investigated. The influences of FERMT1 on expression of glycolysis-related proteins and levels of AT

SUBMITTER: Pan Z 

PROVIDER: S-EPMC11231014 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature