Mitochondrial oxygen tension in critically ill patients receiving red blood cell transfusions: a multicenter observational cohort study.

ABSTRACT:

Purpose

Currently, there is no marker of efficacy of red blood cell (RBC) transfusion. This study describes the impact of RBC transfusion on mitochondrial oxygen tension (mitoPO₂) and mitochondrial oxygen consumption (mitoVO₂) in critically ill patients with anemia.

Methods

Critically ill patients with a hemoglobin concentration < 10 g/dL, for whom a single RBC unit had been ordered, were included. MitoPO₂ was measured with the COMET device immediately before RBC transfusion, 0.5 h, 1 h, 3 h, and 24 h after RBC transfusion. MitoVO₂ was calculated from dynamic mitoPO₂ measurements during cessation of local oxygen supply.

Results

Sixty-three patients participated, median age 64.0 (interquartile range (IQR) 52.3-72.8

SUBMITTER: Baysan M 

PROVIDER: S-EPMC11231106 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature