Investigating the causal association between obesity and risk of hepatocellular carcinoma and underlying mechanisms.

ABSTRACT: Obesity is a global health concern and independent risk factor for cancers including hepatocellular carcinoma (HCC). However, evidence on the causal links between obesity and HCC is limited and inconclusive. This study aimed to investigate the causal relationship between obesity-related traits and HCC risk and explore underlying mechanisms using bioinformatics approaches. Two-sample Mendelian randomization analysis was conducted leveraging publicly available genome-wide association study summary data on obesity traits (body mass index, body fat percentage, waist circumference, waist-to-hip ratio, visceral adipose tissue volume) and HCC. Associations of obesity with primary mechanisms (insulin resistance, adipokines, inflammation) and their effects on HCC were examined. Differentially expre

SUBMITTER: Chen Z 

PROVIDER: S-EPMC11231137 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature