Coordinated inflammation and immune response transcriptional regulation in breast cancer molecular subtypes.

ABSTRACT: Breast cancer, characterized by its complexity and diversity, presents significant challenges in understanding its underlying biology. In this study, we employed gene co-expression network analysis to investigate the gene composition and functional patterns in breast cancer subtypes and normal breast tissue. Our objective was to elucidate the detailed immunological features distinguishing these tumors at the transcriptional level and to explore their implications for diagnosis and treatment. The analysis identified nine distinct gene module clusters, each representing unique transcriptional signatures within breast cancer subtypes and normal tissue. Interestingly, while some clusters exhibited high similarity in gene composition between normal tissue and certain subtypes, others showed low

SUBMITTER: Velazquez-Caldelas TE 

PROVIDER: S-EPMC11231215 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature