Synergistic antitumor activity by dual blockade of CCR1 and CXCR2 expressed on myeloid cells within the tumor microenvironment.

ABSTRACT:

Background

Chemokine signaling within the tumor microenvironment can promote tumor progression. Although CCR1 and CXCR2 on myeloid cells could be involved in tumor progression, it remains elusive what effect would be observed if both of those are blocked.

Methods

We employed two syngeneic colorectal cancer mouse models: a transplanted tumor model and a liver metastasis model. We generated double-knockout mice for CCR1 and CXCR2, and performed bone marrow (BM) transfer experiments in which sub-lethally irradiated wild-type mice were reconstituted with BM from either wild-type, Ccr1^-/-, Cxcr2^-/- or Ccr1^-/-Cxcr2^-/- mice.

Results

Myeloid cells that express MMP2, MMP9 and VEGF were accumulated around both types of tumors through

SUBMITTER: Masui H 

PROVIDER: S-EPMC11231281 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature