Empagliflozin rescues pro-arrhythmic and Ca²⁺ homeostatic effects of transverse aortic constriction in intact murine hearts.

ABSTRACT: We explored physiological effects of the sodium-glucose co-transporter-2 inhibitor empagliflozin on intact experimentally hypertrophic murine hearts following transverse aortic constriction (TAC). Postoperative drug (2-6 weeks) challenge resulted in reduced late Na⁺ currents, and increased phosphorylated (p-)CaMK-II and Nav1.5 but not total (t)-CaMK-II, and Na⁺/Ca²⁺ exchanger expression, confirming previous cardiomyocyte-level reports. It rescued TAC-induced reductions in echocardiographic ejection fraction and fractional shortening, and diastolic anterior and posterior wall thickening. Dual voltage- and Ca²⁺-optical mapping of Langendorff-perfused hearts demonstrated that empagliflozin rescued TAC-induced increases in action potential durations

SUBMITTER: Wen Q 

PROVIDER: S-EPMC11231339 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature