Development and validation of a faecal immunochemical test-based model in the work-up of patients with iron deficiency anaemia.

ABSTRACT:

Objective

In patients with iron deficiency anaemia (IDA), the diagnostic yield of gastroscopy and colonoscopy (bidirectional endoscopy) in detecting neoplastic lesions is low. This study aimed to develop and validate a faecal immunochemical test (FIT)-based model to optimise the work-up of patients with IDA.

Methods

Outpatients with IDA were enrolled in a prospective, multicentre study from April 2016 to October 2019. One FIT was performed before bidirectional endoscopy. Significant gastrointestinal lesions were recorded and a combined model developed with variables that were independently associated with significant colorectal lesions in the multivariate analysis. The model cut-off was selected to provide a sensitivity of at least 95% for colorectal cancer (CRC) detection,

SUBMITTER: Hernandez G 

PROVIDER: S-EPMC11231424 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature