Characterizing genetic profiles for high triglyceride levels in U.S. patients of African ancestry.

ABSTRACT: Hypertriglyceridemia (HTG) is a common cardiovascular risk factor characterized by elevated triglyceride (TG) levels. Researchers have assessed the genetic factors that influence HTG in studies focused predominantly on individuals of European ancestry. However, relatively little is known about the contribution of genetic variation of HTG in people of African ancestry (AA), potentially constraining research and treatment opportunities. Our objective was to characterize genetic profiles among individuals of AA with mild-to-moderate HTG and severe HTG versus those with normal TGs by leveraging whole-genome sequencing data and longitudinal electronic health records available in the All of Us program. We compared the enrichment of functional variants within five canonical TG metabolism genes, a

SUBMITTER: Jiang L 

PROVIDER: S-EPMC11231545 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature