Depressed patients with childhood maltreatment display altered intra- and inter-network resting state functional connectivity.

ABSTRACT:

Background

Childhood maltreatment (CM) is a major risk factor for the development of major depressive disorder (MDD). To gain more knowledge on how adverse childhood experiences influence the development of brain architecture, we studied functional connectivity (FC) alterations of neural networks of depressed patients with, or without the history of CM.

Methods

Depressed patients with severe childhood maltreatment (n = 18), MDD patients without maltreatment (n = 19), and matched healthy controls (n = 20) were examined with resting state functional MRI. History of maltreatment was assessed with the 28-item Childhood Trauma Questionnaire. Intra- and inter-network FC alterations were evaluated using FMRIB Software Library and CONN toolbox.

Results

We found numerous intra

SUBMITTER: Galber M 

PROVIDER: S-EPMC11231604 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature