Reciprocal regulation of cardiac β-oxidation and pyruvate dehydrogenase by insulin.

ABSTRACT: The heart alters the rate and relative oxidation of fatty acids and glucose based on availability and energetic demand. Insulin plays a crucial role in this process diminishing fatty acid and increasing glucose oxidation when glucose availability increases. Loss of insulin sensitivity and metabolic flexibility can result in cardiovascular disease. It is therefore important to identify mechanisms by which insulin regulates substrate utilization in the heart. Mitochondrial pyruvate dehydrogenase (PDH) is the key regulatory site for the oxidation of glucose for ATP production. Nevertheless, the impact of insulin on PDH activity has not been fully delineated, particularly in the heart. We sought in vivo evidence that insulin stimulates cardiac PDH and that this process is driven by the inhibit

SUBMITTER: Elnwasany A 

PROVIDER: S-EPMC11231754 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature