Vaginal Progesterone for Pregnancy Prolongation After Arrested Preterm Labor: A Randomized Clinical Trial.

ABSTRACT:

Importance

Women with arrested preterm labor (APTL) are at very high risk for spontaneous preterm delivery (SPTD), the leading cause of neonatal mortality and morbidity. To date, no maintenance therapy has been found to be effective for pregnancy prolongation. A few clinical trials with considerable methodological limitations have demonstrated some efficacy for 400 mg vaginal micronized progesterone (VMP) in women with APTL.

Objective

To investigate the effectiveness of daily 400 mg VMP for the prolongation of pregnancy after APTL.

Design, setting, and participants

This randomized clinical trial was conducted between December 19, 2018, and February 27, 2023, in 3 university-affiliated medical centers in Israel. Participants included women with singleton and twin pregn

SUBMITTER: Nachum Z 

PROVIDER: S-EPMC11231798 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature