A signature of four ferroptosis-related genes in laryngeal squamous cell carcinoma.

ABSTRACT:

Background

Laryngeal squamous cell carcinoma (LSCC) prognosis has not improved significantly in the past few decades, and more effective treatments are needed to be explored. Ferroptosis is a newly discovered kind of regulated cell death in recent years, which is related to tumor immunity and can used to treat tumors. Therefore, the prognostic value of ferroptosis-related genes in laryngeal cancer needs further clarification.

Methods

In this study, the mRNA expression profile data of LSCC were downloaded from the public database. After identifying ferroptosis-related differentially expressed genes (FDGs), we explored the role of these genes through functional enrichment analysis. FDGs with prognostic significance were identified by univariate Cox and least absolute shrinkage

SUBMITTER: Zhao R 

PROVIDER: S-EPMC11231803 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature