Identification and validation of Cystatin A as a novel promising therapeutic target for gastric cancer.

ABSTRACT:

Background

The effect of pharmacological treatment of gastric cancer (GC) is limited, thus, it holds significant scientific importance to thoroughly investigate the molecular mechanisms underlying GC development and identify novel molecules capable of substantially extending patients' survival. This study utilized bioinformatics techniques to identify 11 genes associated with recurrence-free survival (RFS) in GC patients and investigated the potential biological functions of these genes through single-cell transcriptomic analysis. Subsequently, a single gene Cystatin A (CSTA) was selected for further analysis to explore its impact on signaling pathways and treatment.

Methods

Differentially expressed genes (DEGs) were identified and overlapped in the analysis of RFS to identi

SUBMITTER: Xu Q 

PROVIDER: S-EPMC11231850 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature