Developmental programming: Testosterone excess masculinizes female pancreatic transcriptome and function in sheep.

ABSTRACT: Hyperandrogenic disorders, such as polycystic ovary syndrome, are often associated with metabolic disruptions such as insulin resistance and hyperinsulinemia. Studies in sheep, a precocial model of translational relevance, provide evidence that in utero exposure to excess testosterone during days 30-90 of gestation (the sexually dimorphic window where males naturally experience elevated androgens) programs insulin resistance and hyperinsulinemia in female offspring. Extending earlier findings that adverse effects of testosterone excess are evident in fetal day 90 pancreas, the end of testosterone treatment, the present study provides evidence that transcriptomic and phenotypic effects of in utero testosterone excess on female pancreas persist after cessation of treatment, suggesting lastin

SUBMITTER: Halloran KM 

PROVIDER: S-EPMC11231987 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature