Mild Photochemical Reduction of Alkenes and Heterocycles via Thiol-Mediated Formate Activation.

ABSTRACT: The reduction of alkenes to their respective alkanes is one of the most important transformations in organic chemistry, given the abundance of natural and commercial olefins. Metal-catalyzed hydrogenation is the most common way to reduce alkenes; however, the use of H₂ gas in combination with the precious metals required for these conditions can be impractical, dangerous, and expensive. More complex substrates often require extremely high pressures of H₂, further emphasizing the safety concerns associated with these hydrogenation reactions. Here we report a safe, cheap, and practical photochemical alkene reduction using a readily available organophotocatalyst, catalytic thiol, and formate. These conditions reduce a variety of di-, tri-, and tetra-substituted alkenes i

SUBMITTER: Brzezinski CU 

PROVIDER: S-EPMC11232005 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature